What is PZA medicine
Recently, the discussion on "What drug is PZA" has attracted attention in the field of medical and health. PZA (pyrazinamide) is an anti-tuberculosis drug that is commonly used in combination treatment of tuberculosis. This article will introduce you to PZA in detail the relevant information about PZA based on the popular topics and hot contents of the entire network for the past 10 days.
1. Basic information of PZA
PZA (pyrazinamide) is a synthetic antibacterial drug that is mainly used in the treatment of tuberculosis. It can significantly improve the therapeutic effect by inhibiting the growth of Mycobacterium tuberculosis and in combination with other anti-tuberculosis drugs.
| project | content |
|---|---|
| Common name | Pyrazinamide |
| English abbreviation | PZA |
| Indications | Tuberculosis (combined with other anti-tuberculosis drugs) |
| Dosage form | Tablets, capsules |
| Common specifications | 500mg/piece |
2. The mechanism of action of PZA
PZA exerts the best antibacterial activity in an acidic environment, and its mechanism of action is to inhibit its growth and reproduction by interfering with the metabolic process of Mycobacterium tuberculosis. Specifically manifested as:
| Mechanism of action | Detailed description |
|---|---|
| Metabolic interference | Inhibiting fatty acid synthesis of tuberculosis bacteria |
| Acid environment activation | The strongest antibacterial activity at pH ≤5.5 |
| Bactericidal effect | It has a unique killing effect on semi-dormant tuberculosis |
3. Usage and dosage of PZA
The usage and dosage of PZA must be strictly followed by medical advice. The following are routine medication guidance:
| crowd | dose | usage |
|---|---|---|
| aldult | 15-30mg/kg/day | Take once a day or 2-3 times a day |
| child | 15-30mg/kg/day | 1 time a day |
| Maximum dosage | 2g/day | - |
4. Side effects and precautions of PZA
According to recent medical forum discussions, PZA may cause the following adverse reactions:
| system | Adverse reactions | Incidence rate |
|---|---|---|
| liver | Elevated liver enzymes, hepatitis | 1-5% |
| metabolism | Hyperuricemia | common |
| Gastrointestinal tract | Nausea, vomiting | common |
| skin | Rash, photosensitive reaction | Rare |
Special attention should be paid to using PZA:
1. Regularly monitor liver function during medication use
2. Avoid drinking
3. Drink more water to prevent hyperuricemia
4. Stop the medicine immediately and seek medical treatment if there is serious adverse reactions
V. The position of PZA in tuberculosis treatment
According to the latest tuberculosis treatment guidelines, PZA is an important part of a standard short-term chemotherapy regimen:
| Treatment options | Drug composition | Treatment |
|---|---|---|
| Standard Solution | Isoniazid + rifampin + PZA + ethambutol | 2-month strengthening period + 4-month consolidation period |
| Drug resistance regimen | Adjustment based on drug sensitivity results, PZA may be retained | 18-24 months |
6. Latest research progress on PZA
Several recent studies published in medical journals have explored the new applications of PZA:
1. Optimized dose research: Exploring the efficacy and safety of higher doses of PZA
2. Research on drug resistance mechanism: Analyzing drug-resistant gene mutations of tuberculosis bacteria to PZA
3. Combination drug research: Synergistic effects of PZA and other novel antituberculosis drugs
7. Patient FAQs
According to data from the medical Q&A platform in the past 10 days, common questions about PZA include:
Q: Do PZA need to be taken on an empty stomach?
A: You can take it on an empty stomach or after a meal, but it is recommended to take it at a fixed time to ensure the stable blood concentration.
Q: Is it normal for the urine to turn red after taking PZA?
A: PZA will not cause urine to discolor. If this happens, seek medical examination in time.
Q: Can PZA be taken with other drugs?
A: Doctors need to be informed of all the drugs being used to avoid drug interactions.
Conclusion
As an important drug for anti-tuberculosis treatment, PZA plays a key role in the prevention and treatment of tuberculosis. Correct use of PZA requires strict compliance with medical advice and regular monitoring of adverse reactions. With the deepening of medical research, the application of PZA will be more accurate and effective. If you have any questions about medication, it is recommended to consult a professional doctor or pharmacist in time.
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